| Pair Name | Euphol, Temozolomide | ||
| Phytochemical Name | Euphol (PubChem CID: 441678 ) | ||
| Anticancer drug Name | Temozolomide (PubChem CID: 5394 ) | ||
| Structure of Phytochemical |
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2D
MOL
3D
MOL
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| Structure of Anticancer Drug |
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MOL
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| Pair Name | Euphol, Temozolomide | |||
| Disease Info | [ICD-11: 2A00] | Glioblastoma multiforme | Investigative | |
| Biological Phenomena | Induction-->Autophagy | |||
| Gene Regulation | Up-regulation | Expression | MAP1LC3B | hsa81631 |
| In Vitro Model | GaMG | Glioblastoma | Homo sapiens (Human) | CVCL_1226 |
| U-373MG ATCC | Astrocytoma | Homo sapiens (Human) | CVCL_2219 | |
| Result | These findings provide experimental support for further development of euphol as a novel therapeutic agent for GBM, either alone or in combination chemotherapy. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Euphol, a tetracyclic triterpene, from Euphorbia tirucalli induces autophagy and sensitizes temozolomide cytotoxicity on glioblastoma cells. Invest New Drugs. 2019 Apr;37(2):223-237. doi: 10.1007/s10637-018-0620-y. | Click |
